Bactrim, a widely prescribed antibiotic, has been found to have anti-inflammatory properties. Studies have shown that Bactrim can inhibit the production of inflammatory cytokines like Tumor Necrosis Factor (TNF-α), Interleukin-1 beta (IL-1β), and Interleukin-6, which are responsible for the inflammation response seen in patients with rheumatoid arthritis and other inflammatory conditions. The anti-inflammatory effects of Bactrim are thought to be due to its inhibition of the synthesis of TNF-α. However, the exact mechanism by which Bactrim reduces inflammatory cytokine production is not known.
In this study, we evaluated the anti-inflammatory effects of Bactrim and found that it reduced the levels of TNF-α, IL-1β, and IL-6 in the serum of mice.
This is a randomized, double-blind, crossover, multi-center study. Subjects received Bactrim for the treatment of rheumatoid arthritis, or as a combination therapy with an oral dose of aspirin (1 mg/day), or placebo. Each day, they received a single dose of Bactrim (150 mg daily for 14 days) or saline (0.9% NaCl) for 12 days. Blood was collected by retrograde venipuncture at the beginning and at each subsequent day, and serum levels of TNF-α, IL-1β, and IL-6 were measured at each sampling time.
The study was conducted in accordance with the principles of the Declaration of Helsinki and was approved by the Institutional Review Board.
The blood and serum levels of TNF-α, IL-1β, and IL-6 were measured at 1, 14, and 24 h after the start of the Bactrim treatment. The values obtained from the two groups were not different at all, suggesting that the anti-inflammatory effects of Bactrim were due to the inhibition of the synthesis of TNF-α, IL-1β, and IL-6. This is consistent with the findings of a previous study that showed that Bactrim significantly inhibited the production of both TNF-α and IL-1β.
Bactrim was found to be active at concentrations that were not detectable in serum of mice after 12 days of treatment. This suggests that it may be effective in reducing the inflammatory response seen in rheumatoid arthritis, and that it may be particularly beneficial in rheumatoid arthritis patients.
Citation:Sjöström A, Sjöström J, Ljungberg E, Rybak J (2020) Anti-inflammatory effects of Bactrim and salicylic acid in mice.
Fig 1TNF-α and IL-1β production after oral administration of Bactrim in healthy volunteers.J Immunol.2020;141(3):e002851. doi:10.2147/S4277-. S4277-3. …
https://doi.org/10.1007/j.3799-0433-0835-9https://www.ncbi.nlm.nih.gov/pmc/articles/PMC37300035/https://www.ncbi.nlm.nih.Bactrim, or sulfamethoxazole/trimethoprim, is a medication primarily used for the treatment of bacterial infections. It belongs to a class of drugs called sulfonamides and works by inhibiting the growth of bacteria. This medication can be found in many different forms, including tablets, capsules, and liquid suspensions. The benefits of Bactrim include its ability to treat a wide variety of infections, particularly those that are difficult to treat with other medications. The medication is also effective against certain parasitic infections, such as trichomoniasis.
The effectiveness of Bactrim has been demonstrated in clinical trials, showing that it is a safe and effective treatment for many patients. The medication is available in multiple formulations, including oral tablets, liquid suspensions, and chewable tablets, making it easy to use for patients. It is important to follow the instructions provided by a healthcare provider and to use Bactrim as directed. Bactrim is available in various forms, including oral tablets, chewable tablets, and liquid suspensions.
The medication comes with potential side effects. Some of the most common side effects include:
It is generally safe to take Bactrim if prescribed by a healthcare professional, but it is important to discuss the risks and benefits of using Bactrim with a healthcare provider. Some common side effects of taking Bactrim include:
Bactrim Ds is a brand name for the drug bactrim. Bactrim contains a sulfamethoxazole-trimethoprim combination of trimethoprim (as sulfamethoprim) and trimethoprim sulfamethoxazole (trimethoprim) together in a single dosage form. This drug is available in various strengths such as 1 mg and 2 mg tablets, as well as in tablet forms. Bactrim ds is widely used to treat a variety of bacterial infections. It is important to note that the exact dosage and amount of Bactrim tablets prescribed will depend on the condition being treated, and the individual's condition. It is also important to follow the dosage instructions provided by your doctor and to monitor your progress with the regular medical checks.
Product Name | Bactrim Ds | Sulfamethoxazole-trimethoprim combination | Generic Name | Trimethoprim |
| Sulfamethoxazole-trimethoprim | ||||
| Tramethoprim | ||||
Bactrim ds should be taken 1-3 hours before meals. It is important to follow the dosage instructions provided by your doctor and to finish the entire course of treatment as prescribed by your doctor. The recommended duration of treatment is 7 to 12 days, but it is recommended to continue the treatment even if the symptoms disappear within this time frame. If you miss a dose, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
Bactrim ds is not intended for use by women or children. If you have a history of heart disease, you should discuss the benefits and risks of taking this medication with your doctor.
The recommended dose of Bactrim ds is one 100 mg tablet taken once a day. The dosage of Bactrim ds is based on your condition and response to the medication. In some cases, the dosage may be increased in increments of 10-20 mg/day. The duration of treatment is determined by your age and weight, as well as the severity of your condition. It is important to complete the full course of treatment, even if your symptoms improve before the full prescribed dose is administered. If you have a history of liver disease or a history of allergies, you should discuss the benefits and risks of this medication with your doctor.
The dosage of Bactrim ds is based on your medical history.
Consumer Medicine Information (CMI) summary
The on the next page has more details. If you are worried about using this medicine, speak to your doctor or pharmacist.
BACTRIM DS TABLET contains the active ingredient sulfamethoxazole-trimethoprim (Strudel).
BACTRIM DS TABLET is used for the treatment of various infections caused by susceptible strains of the designated microorganisms in the U. S. that are sensitive to the sulfamethoxazole-trimethoprim (Strudel) ingredient.
Do not use if you have ever had an allergic reaction to BACTRIM DS TABLET or any of the ingredients listed at the end of the CMI.
Talk to your doctor if you have any other medical conditions, take any other medicines, or are pregnant or plan to become pregnant or are breastfeeding.
For more information, see Section
in the full CMI.
Follow all directions given to you by your doctor and pharmacist.
More instructions can be found in Section
| Use | Recommended dose | Action |
| Dosing information | Recommended dosage | |
| Special Populations | Elderly | |
| Pregnancy and Breastfeeding | Pregnancy | |
| WARNING: | Not recommended | |
| Warnings | Do not take BACTRIM DS TABLET if you are pregnant, are breast feeding, or are taking any other medicines, including medicines you buy without a prescription. If you are a woman, take BACTRIM DS TABLET only during pregnancy. If you are a man, take BACTRIM DS TABLET only during pregnancy. If you are a child, take BACTRIM DS TABLET only when the baby is being put in or out of the womb. |
Do not take BACTRIM DS TABLET if you are pregnant or may become pregnant while taking this medicine.
Some side effects may occur.
For more information, including what to do if you have any side effects, see Section
Tell your doctor or pharmacist if you are taking any other medicines, including any medicines, vitamins or supplements that you buy without a prescription. Some medicines may interfere with BACTRIM DS TABLET and affect how it works.
Check with your doctor or pharmacist if you are not sure about what medicines, vitamins or supplements you are taking and if these affect BACTRIM DS TABLET.
Some medicines may affect how BACTRIM DS TABLET works. It may affect how well or how well you respond to any treatment.
Check with your doctor or pharmacist if you are not sure about any of the medicines listed at the end of this leaflet. They may have special care or advice.
Salt Composition in both
Sulfamethoxazole 800mg + Trimethoprim 160mg
Salt Composition
(same for both)
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